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Engineered with genetic elements from human cells that: o Govern the cellular ... a stable expression of the transgene, without integrating into the cells genome.
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GMP LENTIVIRUS SPECIALIZED CDMO

VIVEbiotech´s introduction

Prior experience

Key Milestones Since VIVEbiotech was created, the following milestones have been reached: •

GMP certification has been obtained



Sealed as Excellence Centre



Customers in USA and Europe



FDA adaptation



Double-manufacturing capacity



Commercial manufacturing capacities

CDMO

CDMO Specialized in the manufacture of Research, Preclinical toxicology and GMP-grade lentiviral vectors.

CDMO: related services

Lentisoma

Lentisoma Non-Integrative Lentiviral episomal vector

Safety-related aspects

Engineered with genetic elements from human cells that: o Govern the cellular process of genome division o Equally segregation of chromosomes in daughter cells upon cell division.

These elements are: o Ori that marks the vector to be recognised and duplicated by the cell o Scaffold/matrix attachment region (SMAR) a DNA sequence which anchors the vector genome (containing the therapeutic gene) to the nuclear matrix, avoiding its integration within the cell genome.

Lentisoma The vector genome to persist through cell divisions and concomitantly maintain a stable expression of the transgene, without integrating into the cells genome. o VIVEbiotech has secured exclusive rights to proprietary IP: ▪ Priority date 27th November 2013 ▪ National phases May 2016: Europe; USA; Israel; Canada; Japan; China and Australia

Our facilities Potenciales clientes renombrados en el mercado VIVEbiotech´s building: • Lab • Offices

Our facilities Potenciales clientes renombrados en el mercado R&D Lab

Our facilities Potenciales clientes renombrados en el mercado GMP area: USP

Our facilities Potenciales clientes renombrados en el mercado GMP area: DSP

Our team

o 40% PhDs o Multidisciplinar o Low turn-over rate o Continued increase in employees number

GMP LENTIVIRUS SPECIALIZED CDMO