medicamentos del Fondo Estratégico - Pan American Health

rifampicina para el tratamiento de segunda línea de la lepra. 5 ... 600mg. Tablet. Emtricitabine. 200mg. Capsule adversos o efectos tóxicos relacionados al ...
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Strategic Fund Medicine List / Lista de Medicamentos del Fondo Estratégico1 Updated August 11 2017 International Nonproprietary Name (INN) / Denominación Común Internacional (DCI) ANALGESICS Opioid analgesics Codeine

Strength / Concentracion

15mg; 30mg (phosphate) 10mg/ml (sulfate or hydrochloride) in 1ml ampoule 10mg/5ml (sulfate or hydrochloride)

Morphine Morphine Morphine

10mg; 30mg; 60mg (sulfate)

ANTI-INFECTIVE MEDICINES Antibacterial Amoxicillin + Clavulanic acid Azithromycin Azithromycin (for Trachoma treatment)

Benzathine benzylpenicillin

Benzylpenicillin

Procaine benzylpenicillin

500mg + 125mg 200mg/5ml 250mg; 500mg (anhydrous) 900 mg benzylpenicillin (=1.2 million IU) in 5mL vial; 1.44 g benzylpenicillin (=2.4 million IU) in 5mL vial 600 mg (=1 million IU) (sodium or potassium salt) in vial; 3 g (=5 million IU) (sodium or potassium salt) in vial 1 g (=1 million IU); 3 g (= 3 million IU) in vial

Doxycycline

100mg (hydrochloride)

Sulfadiazine

500mg

1

Presentation / Forma Farmacéutica

Tablet

Indication(s)/ Indicacion(es)

Analgesic

Injection

Analgesic; Anaesthetic; Preoperative and short procedures

Oral Solution

Analgesic; Palliative care

Tablet (prolonged release)

Analgesic; Palliative care

Tablet Oral Solution Tablet

Antibacterial Antibacterial

Powder for injection

Antibacterial; Syphilis

Powder for injection

Antibacterial; Syphilis

Powder for injection

Antibacterial; Syphilis

Tablet; Capsule Tablet

Ref

Antibacterial; Malaria prophylaxis and treatment Anti-pneumocystosis; Anti-toxoplasmosis

The therapeutic indications presented in this list of medicines appear as published in the 20th World Health Organization Model List of Essential Medicines published March 2017. The Strategic Fund Medicine List does not seek to replace or complement the WHO the Essential Medicine List or Member States national essential medicine lists. As a result, this list should not be utilized as reference for the development of other essential medicine lists or treatment guidelines. - Las indicaciones terapéuticas se presentan con base en la decimonovena Lista de Medicamentos Esenciales de la Organización Mundial de la Salud publicada en Marzo 2017. La Lista de Medicamentos del Fondo Estratégico no supone ninguna complementación o ampliación de la Lista de Medicamentos Esenciales de la OMS o de las listas de medicamentos esenciales nacionales de los Estados Miembros. Consecuenteme nte, esta lista no debería ser utilizada como referencia para la elaboración de listas de medicamentos esenciales o guías de tratamiento. 2 Only used as single dose treatment of genital Chlamydia Trachomatis and of trachoma. - Solamente utilizado en dosis única para el tratamiento de chlamydia trachomatis genital y tracoma.

2

Strategic Fund Medicine List / Lista de Medicamentos del Fondo Estratégico Antileprosy med. Clofazimine Dapsone Ofloxacin Antituberculosis med.

50mg; 100mg 25mg; 50mg; 100mg 400mg

Capsule Tablet Tablet

Ethambutol Isoniazid

100mg; 400mg (hydrochloride) 25mg/ml 50mg/5ml

Isoniazid

100mg

Isoniazid Pyrazinamide

300mg 400mg

Pyrazinamide

150mg

Pyrazinamide Rifabutin Rifampicin

30mg/ml 150mg 20mg/ml

Oral Solution Oral Solution Tablet (dispersable) Tablet Tablet Tablet (scored); Tablet (dispersible) Oral Solution Capsule Oral Solution

Rifampicin

150mg; 300 mg

Tablet; Capsule

Rifampicin + Isoniazid

75mg + 50mg

Rifampicin + Isoniazid

60mg + 30mg

Ethambutol

Rifampicin + Isoniazid + Ethambutol

150mg + 75mg ; 300mg + 150mg; 60mg + 60mg; 150mg + 150mg 150mg + 75mg + 275mg

Rifampicin + Isoniazid + Pyrazinamide

75mg + 50mg + 150mg

Rifampicin + Isoniazid + Pyrazinamide

60mg + 30mg + 150mg

Rifampicin + Isoniazid

Rifampicin + Isoniazid + Pyrazinamide Rifampicin + Isoniazid + Pyrazinamide + Ethambutol Rifapentine nd Antiberculosis med. 2 line

150mg + 75mg + 400mg; 150mg + 150mg + 500mg 150mg + 75mg + 400mg + 275mg 150mg

Amikacin

1g (sulfate) in vial

Bedaquiline

100mg

Leprosy

3

Leprosy (second-line)

4

Tablet

Tuberculosis

5

Tuberculosis; Leprosy

Tablet (dispersable) Tablet (dispersable) Tablet Tablet Tablet (dispersable) Tablet (dispersable)

Tuberculosis

Tablet Tablet 6

Tablet Powder for Injection Tablet

Multidrug-resistant tuberculosis (MDR/TB)

3

Medicines used in the treatment of leprosy should never be used except in combination. - Los medicamentos para el tratamiento de lepra siempre deben ser utilizados en combinación. 4 To be used in combination with rifampicin as a second-line therapy for leprosy treatment. - Para ser utilizado en combinación con rifampicina para el tratamiento de segunda línea de la lepra. 5 For use in patient with HIV receiving protease inhibitors. - Para el uso en pacientes con VIH que reciben inhibidores de proteasa. 6

3

For treatment of latent tuberculosis infection only – Para el tratamiento de la tuberculosis latente unicamente.

7

Procurement of this medicine through the Strategic Fund should be limited for use according to WHO recommended M/XDR-TB regimen in patients for whom there are few or no treatments available. Patients receiving this medicine should be monitored for potential adverse events or related toxicities through national pharmacovigilance programs and data from the WHO Programme for International Drug Monitoring (UPPSALA). - La adquisición de este medicamento a través del Fondo Estratégico debe ser limitada para el uso en pacientes con tuberculosis multi y extensivamente resistente (M-XDR TB) en que hay pocos o ningún tratamiento disponibles y usado según el regimen recomendado por la OMS para M-XDR-TB. Los pacientes que reciben este medicamento deben ser controlados para posibles eventos

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7

Strategic Fund Medicine List / Lista de Medicamentos del Fondo Estratégico Powder for Injection Capsule Capsule Tablet Tablet Tablet Powder for Injection

Capreomycin

0.5g; 1g (sulfate) in vial

Clofazimine Cycloserine Cycloserine Delamanid Ethionamide

50mg; 100mg 250mg 250mg 50mg 125mg ; 250mg

Kanamycin

1g (sulfate) in vial

Levofloxacin

250mg ; 500mg; 750mg

Tablet

Linezolid

600mg

Tablet

7

Linezolid

100mg/5ml

Powder for Oral Solution

7

Moxifloxacin

400mg

Tablet

Protionamide

250mg

Tablet

P-aminosalicylic acid

4g in sachet

P-aminosalicylate sodium (PAS sodium)

100g (60% w/w)

Streptomycin

1g ( sulfate) in vial

Terizidone

250mg

Multidrug-resistant tuberculosis (MDR/TB)

8

Granule Granules Powder for Injection 9

Capsule

Antifungal Amphotericin B

50mg ( sodium deoxycholate or liposomal complex) in vial

Powder for Injection

Antifungal; Anti-Lesihmaniasis

Antivirals Antiretrovirals Abacavir

60mg

Abacavir

300mg

Abacavir + Lamivudine

60mg + 30mg; 120mg + 60mg

Abacavir + Lamivudine Atazanavir Atazanavir Atazanavir + Ritonavir Darunavir Dolutegravir Efavirenz Efavirenz Emtricitabine

600mg + 300mg 100mg 300mg 300mg + 100mg 75mg; 150mg; 400mg; 600mg; 800mg 50mg 200mg 600mg 200mg

Tablet (dispersible, scored) Tablet Tablet (dispersible, scored) Tablet Capsule Capsule Tablet

HIV/AIDS

10

Tablet Tablet Tablet (scored) Tablet Capsule

adversos o efectos tóxicos relacionados al medicamento a través de programas nacionales de farmacovigilancia y datos del Programa de la OMS para la Vigilancia Farmacéutica Internacional (UPPSALA). 8 Protionamide may be an alternative to ethionamide. La protionamida puede ser utilizada como alternativa a la etionamida. 9

Terizidone may be an alternative to cycloserine. La terizidona puede ser utilizada como alternativa a la cicloserina.

10

Age restriction > 3 years old. Restricción de edad > 3 años de edad.

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Strategic Fund Medicine List / Lista de Medicamentos del Fondo Estratégico Etravirine Lamivudine Lamivudine

100mg; 200mg 150mg 10mg/ml

Lamivudine + Zidovudine

30mg +60mg

Lamivudine + Zidovudine

150mg+300mg 100mg + 25mg; 200mg + 50mg

Lopinavir + Ritonavir Lopinavir + Ritonavir

40mg + 10mg

Lopinavir + Ritonavir Nevirapine

80mg+20mg/ml 200mg

Nevirapine

50mg

Nevirapine

50mg/5ml (100ml)

Ritonavir

25mg

Ritonavir

100mg

Ritonavir

400mg/ 5mL (240ml)

Raltegravir

25mg; 100mg

Raltegravir Tenofovir Tenofovir Tenofovir + Emtricitabine Tenofovir + Emtricitabine + Efavirenz Tenofovir + Lamivudine Tenofovir + Lamivudine + Efavirenz Zidovudine

400mg 300mg 200mg 300mg + 200mg 300mg + 200mg + 600mg 300mg + 300mg 300mg + 300mg + 600mg 300mg

Zidovudine

60mg

Zidovudine

50mg/5ml (100ml)

Zidovudine

10mg/ml in 20ml vial

Zidovudine + Lamivudine + Nevirapine

60mg + 30mg + 50mg

Zidovudine + Lamivudine + Nevirapine Other Antivirals

300mg + 150mg + 200mg

Acyclovir

250mg ( sodium salt) in vial

Acyclovir

200mg

Tablet Tablet Oral Solution Tablet (dispersible, scored) Tablet Tablet (heat stable) Oral pellets (heat stable) Oral Solution Tablet Tablet (dispersible, scored) Oral Solution Tablet (heat stable) Tablet (heat stable) Oral solution Tablet (chewable) Tablet Tablet Tablet Tablet Tablet Capsule Tablet Tablet Tablet (dispersible, scored) Oral Solution Solution for IV Infusion Injection Tablet (dispersible, scored) Tablet Powder for Injection Tablet

11

HIV/AIDS 11 11

Herpes Virus

11

Procurement of this medicine through the Strategic Fund should be limited for use as third-line therapy in treatment-experienced HIV adults who failed second-line antiretroviral therapy. It is recommended patients receiving HIV/AIDS regimens including this medicine be monitored for potential adverse events or related toxicities through national pharmacovigilance programs and data from the WHO Programme for International Drug Monitoring (UPPSALA). - La adquisición de este medicamento a través del Fondo Estratégico debe ser limitada para su uso como tratamiento de tercera línea en adultos con VIH tratados previamente que reprobaron la terapia antirretroviral de segunda línea. Se recomienda que los pacientes que reciben regímenes de VIH / SIDA que incluyen este medicamento ser monitorizados para detectar posibles eventos adversos o efectos tóxicos relacionados al medicamento a través de los programas nacionales de farmacovigilancia y los datos del Programa de la OMS para la Vigilancia Farmacéutica Internacional (UPPSALA).

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Strategic Fund Medicine List / Lista de Medicamentos del Fondo Estratégico Oseltamivir

75mg (phosphate)

Oseltamivir

12mg/ml

Anti hepatitis medicines Medicines for Hepatitis B Entecavir Entecavir Tenofovir disoproxil fumarate 13 Medicines for Hepatitis C Daclastavir Dasabuvir Ledipasvir + Sofosbuvir Ombitasvir + Paritaprevir + Ritonavir Simeprevir Sofosbuvir Sofosbuvir + Velpatasvir Antiprotozoal medicines Antileishmaniasis medicines Meglumine antimoniate Amphotericin B Miltefosine

0.05mg/ml 0.5mg; 1mg 300mg 30mg; 60mg 250mg 90mg + 400mg 12.5mg + 75mg + 50mg 150mg 400mg 400mg + 100mg

1.5g/ 5 ml (81 mg/ml) in 5ml ampoule 50mg (sodium deoxycholate or liposomal complex) in vial 10mg; 50 mg

Paromomycin

750mg of paromomycin base (sulfate)

Pentamidine

300mg (isethionate)

Capsule Powder for Oral Solution

Influenza Virus (in compliance with WHO treatement guidelines)

Oral Solution Tablet Tablet

Chronic Hepatitis B

Tablet Tablet Tablet Tablet Capsule Tablet Tablet

Chronic Hepatitis C

Injection

Leishmanaiasis

12

Powder for Injection Tablet Solution for Intramuscular Injection Powder for injection

Leishmanaiasis

Leishmaniasis

14

Anti-malarial Amodiaquine Artemether Artemether + Lumefantrine Artesunate

153 mg; 200 mg (hydrochloride) 80 mg/ml 1 ml ampoule 20 mg + 120 mg 60 mg (anhydrous artesunic acid)

Artesunate

50 mg; 200mg

Artesunate + Mefloquine

100 mg + 220mg

Oily Injection Tablet

Malaria treatment to be used in combination with artesunate for P. falciparum. Severe malaria Malaria treatment

Injection

Severe malaria

Tablet

Rectal Dosage Form Tablet

Severe malaria Malaria treatment

12

According to the 20th World Health Organization Model List of Essential Medicines published in March 2017, Oseltamivir is indicated for severe illness fue to confirmed or suspected influenza virus infection in critically ill hospitalized patients. - De acuerdo con la vigésima Lista Modelo de Medicamentos Esenciales de la Organización Mundial de la Salud publicada en marzo de 2017 Oseltamivir, el uso del oseltamivir es indicado solo en casos confirmados o sospechados de influenza viral en pacientes hospitalizados y en situación de enfermedad critica. (WHO 20th EML 2017) 13 According to the 20th World Health Organization Model List of Essential Medicines published in March 2017 and based on current evidences, medicines of this class act as direct antiviral medicines and are included as essential medicines for treatment of hepatitis C virus infection. WHO guidelines recommend specific combinations therapies utilizing medicines from different classes. - De acuerdo con la vigésima Lista Modelo de Medicamentos Esenciales de la Organización Mundial de la Salud publicada en marzo de 2017 y basándose en la evidencia actual, los medicamentos en esta categoría funcionan como antivirales de acción directa y se incluyen como medicamentos esenciales para el tratamiento de la infección por el virus de la hepatitis C. Las guías de la OMS recomiendan combinaciones terapéuticas específicas con medicamentos de diferentes clases. (WHO 20th EML 2017) 14 This medicine should be used in accordance to the recommendations outlined in the Leishmaniasis in the Americas: Recommendations for the treatment (2013) guide. - Este medicamento debe utilizarse en acuerdo con las recomendaciones formuladas en la guía Leishmaniasis en las Américas: Recomendaciones para el tratamiento (2013). 15 Product may be co-packaged with 1 ampoule of 5% sodium bicarbonate solution and 1 ampoule of sodium chloride solution. Producto puede ser presentado en conjunto con 1 ampolla de solución de bicarbonato sódico y 1 ampolla de solución de cloruro de sodio.

Page 5 of 12

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Strategic Fund Medicine List / Lista de Medicamentos del Fondo Estratégico

Artesunate + Amodiaquine

Atovaquone + Proguanil Atovaquone + Proguanil Chloroquine Chloroquine

25 mg + 67.5 mg (hydrochloride); 50 mg + 135 mg (hydrochloride); 100 mg + 270 mg (hydrochloride) 250+100 mg (hydrochloride) 62.5+25 mg (hydrochloride) 50 mg (phosphate or sulfate)/5 ml 100 mg; 150 mg (phosphate or sulfate)

Tablet

Tablet (adult) Tablet (pediatric)

Malaria prophylaxis and treatment Tablet

250 mg (hydrochloride)

Tablet

Dihydroartemisinina + Piperaquina

40 mg + 320 mg

Tablet

Primaquine

5mg; 7.5 mg ; 15 mg (diphosphate)

Tablet

Quinine Sulfadoxine + Pyrimethamine

300 mg quinine hydrochloride/ml in 2ml ampoule 300 mg (quinine sulfate or bisulfate) 500 mg + 25 mg

Antipneumocystosis and antitoxoplasmosis medicines Pyrimethamine 25mg 80mg + 16mg/ml in 5ml or Sulfamethoxazole + Trimethoprim 10ml ampoule Pentamidine 200mg; 300mg Antitrypanosomal medicines 12.5 mg Benznidazole 50 mg 100mg

Malaria prophylaxis and treatment

Oral Solution

Mefloquine

Quinine

Malaria treatment

Malaria prophylaxis; Malaria treatment to be used in combination with artesunate for P. falciparum Malaria treatment As complement to malaria treatment (for radical cure of P.vivax and P.ovale and as gametocytocide for P. falciparum)

Injection

Severe malaria

Tablet

Malaria treatment

Tablet

Malaria treatment to be used in combination with artesunate for P. falciparum

Tablet Injection

Pneumocystis; Toxoplasmosis

Tablet Tablet Tablet (scored) Tablet

American Trypanosomiasis

120mg

Tablet

African Trypanosomiasis (2nd stage); American Trypanosomiasis

Albendazole

400mg

Tablet (chewable)

Intestinal Anthelminthic; AntiFilarial

Ivermectin

3mg

Tablet (scored)

Strongyloidiasis Intestinal anthelminthic Intestinal anthelminthic (for use when praziquantel fails) Anticestodes

Nifurtimox Anthelminthics Intestinal anthelminthics

Mebendazole

500mg

Tablet (chewable)

Niclosamide

500mg

Tablet (chewable)

Page 6 of 12

Strategic Fund Medicine List / Lista de Medicamentos del Fondo Estratégico Praziquantel

150mg; 600mg

Tablet

Intestinal anthelminthic;

Praziquantel

600mg

Tablet

Antischistosomal; Antitrematode; Anticestode

Tablet

Antitischistosomal; Antitrematode

Antischistosomals and Antitrematode Medicines Triclabendazole

250mg

Antifilarials 50mg; 100mg Tablet (dihydrogen citrate) ANTINEOPLASTIC, IMMUNOSUPPRESSIVES AND MED. USED IN PALLIATIVE CARE Immunosuppressive Agents Dietylcarbamazine

Filariasis

Powder for Injection

Immunosuppressive

50mg

Tablet

DMARD

Cyclosporine

25mg

Capsule

Cyclosporine

50mg/ml in 1ml ampoule

Injection

250 mg

Capsules

500 mg

Tablets Capsules (immediate release)

Azathioprine

100mg (sodium salt) in vial

Azathioprine

Mycophenolate Mofetil

Tacrolimus

0.5, 1, 5 mg

Immunosuppressive Prophylaxis of organ rejection in adult patients receiving allogeneic renal transplants Prophylaxis of organ rejection in adult patients receiving allogeneic renal or hepatic transplants

Cytotoxic medicines Asparaginase

10,000 IU in vial

Bleomycin

15mg (sulfate) in vial

Calcium folinate

3mg/ml in 10ml ampoule

Calcium folinate

15mg

Carboplatin

150mg; 450mg

Chlorambucil

2mg

Cisplatin

10mg; 50mg

Cyclophosphamide

500mg in vial

Cyclophosphamide

25mg

Cytarabine

100mg in vial

Dacarbazine

100mg in vial

Dactinomycin

500µg in vial

Daunorubicin

50mg (hydrochloride) in vial

Docetaxel

20mg/ml 10mg; 50mg (hydrochloride) in vial 100mg 20mg/ml in 5ml ampoule 50mg/ml in ampoule

Doxorubicin Etoposide Etoposide Fluorouracil

Powder for Injection Powder for Injection Injection Tablet Powder for Injection Tablet Powder for Injection Powder for Injection Tablet Powder for Injection Powder for Injection Powder for Injection Powder for Injection Injection Powder for Injection Capsule Injection Injection

Cytotoxic Agent

Adjuvant Medicine Cytotoxic and Adjuvant Medicine Cytotoxic Agent Cytotoxic and Adjuvant Medicine Cytotoxic Agent

Cytotoxic Agent

Cytotoxic and Adjuvant Medicine Cytotoxic Agent Cytotoxic and Adjuvant Medicine Page 7 of 12

Strategic Fund Medicine List / Lista de Medicamentos del Fondo Estratégico

Ifosfamide

1g vial

Mercaptopurine Mesna (2-mercaptoethane sulfonate sodium)

50mg 100mg/ml in 4ml and 10ml ampoules

Methotrexate

50mg (sodium salt) in vial

Methotrexate

2.5mg (sodium salt)

Paclitaxel

6mg/ml

Procarbazine Tamoxifen

50mg (hydrochloride) 10mg; 20mg (citrate)

Trastuzumab

150 & 440 mg

Vinblastine

10mg (sulfate) in vial

Vincristine

1mg; 5mg (sulfate) in vial

Powder for Injection Tablet

Cytotoxic and Adjuvant Medicine Cytotoxic Agent

Injection

Adjuvant Medicine

Powder for Injection

Cytotoxic Agent

Tablet

Cytotoxic Agent; DMARD

Powder for Injection Capsule Tablet Powder for injection Powder for Injection Powder for Injection

Cytotoxic and Adjuvant Medicine Cytotoxic Agent Hormone/Anti-Hormone HER2+ early breast cancer

Cytotoxic Agent

BLOOD PRODUCTS AND PLASMA SUBSTITUTES Plasma fractions for specific use Human normal immunoglobulin

16% protein solution

Human normal immunoglobulin

5% protein solution; 10% protein solution

Coagulation factor VIII

500UI/vial

Coagulation factor IX

500UI/vial; 1000UI/vial

Injection for Intramuscular Administration Injection for Intravenous Administration Powder for injection Powder for injection

16

Plasma fractions for specific use 17

Blood coagulation factors

IMMUNOBIOLOGICS Sera and immunoglobulins anti-D immunoglobulin (human)

250µg in single-dose vial

Injection

Prevention of newborn hemolytic illnesses; Rh negative populations (prophylaxis)

Tablet

Antihypertensive

Tablet

Antihypertensive; Antianginal; Antiarrhythmic; Medicines used in heart failure Hypertension in adults Antihypertensive; Medicines used in heart failure

CARDIOVASCULAR MEDICINES Antihypertensive medicines Amlodipine Bisoprolol Carvedilol Chlorthalidone Enalapril Hydralazine Hydralazine

16

5mg (maleate, mesylate or besylate) 1.25mg; 5mg 3.125mg; 6.25mg; 12.5mg; 25mg; 50mg 12.5mh; 25mg 2.5mg; 5mg (hydrogen maleate) 20mg (hydrochloride) in ampoule 25mg; 50mg

Tablet Tablet Tablet Powder for Injection Tablet

Hypertension

Indicated for primary immune deficiency. - Indicado para deficiencia inmune primaria.

17

Indicated for primary immune deficiency and Kawasaki disease. - Indicado para deficiencia inmune primaria y enfermedad de Kawasaki. 18 Metoprolol and carvedilol as alternatives. - Alternativos: metoprolol y carvedilol. Page 8 of 12

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Strategic Fund Medicine List / Lista de Medicamentos del Fondo Estratégico

(hydrochloride) Hydrochlorothiazide

12.5mg; 25mg

Tablet

Losartan Methyldopa

25mg; 50mg; 100mg 250 mg

Tablets Tablet

Metoprolol

100mg

Tablet

Sodium nitroprusside

50mg in ampoule

Surfactant (Surfactante pulmonar exogeno)

25mg/ml; 80mg/ml

Powder for Infusion Suspension for Intratracheal Instillation

Antihypertensive; Medicines used in heart failure; Diuretics Hypertension in adults Antihypertensive Antihypertensive; Antianginal; Antiarrhythmic; Medicines used in heart failure Hypertension Neonatal care

Antiarrhythmic medicines 100 mg; 200 mg; 400 mg (hydrochloride) 50 mg (hydrochloride)/ mL in 3‐ mL ampoule 250 micrograms/ml in 2‐ml ampoule

Amiodarone

Digoxin

62.5 micrograms; 250 micrograms 50 micrograms/ml 20 mg (hydrochloride)/ml in 5‐ml ampoule 2.5 mg (hydrochloride)/ml in 2‐ml ampoule 40 mg; 80 mg (hydrochloride)

Lidocaine

Verapamil

Tablet Antiarrythmic Injection Injection Tablet

Antiarrythmic Medicines used in heart failure

Oral Solution Injection Injection

Antiarrythmic

Tablet

Antiarrythmic Antianginal medicines

Diuretics Spironolactone Antianginal medicines

25mg

Tablet

Diuretic

Glyceryl trinitrate

500µg

Tablet (sublingual)

Angina

Tablet

Prevention of atherothrombotic events in adults with non-ST segment elevation acute coronary syndrome

Powder for Injection

Thrombosis

Tablet

Lipid-Lowering Agents

Antithrombotic medicines Clopidogrel

75 mg

Streptokinase

1.5million IU in vial

Lipid-lowering agents Simvastatin DIAGNOSTIC AGENTS Radiocontrast media

5mg; 10mg; 20mg; 40mg

19

Losartan can be used as an alternative for treatment of adults with hypertension for those patients in whom ACEi are indicated but not tolerated, specifically due to the presence of adverse events (mainly cough); including the sub-population of hypertensive patients associated with type II diabetes with proteinuria. - Losartan puede ser utilizado como una alternativa para el tratamiento de hipertensión en adultos, para aquellos pacientes en los cuales los IECA están indicados pero no se toleran, específicamente debido a la presencia de eventos adversos (principalmente la tos); incluyendo la sub-población de pacientes hipertensos con asociación de diabetes tipo II con proteinuria. 20 Methyldopa is listed for use only in the management of pregnancy‐induced hypertension. Its use in the treatment of essential hypertension is not recommended in view of the evidence of greater efficacy and safety of other medicines (WHO 20th EML). - Metildopa se lista sólo para su uso en el manejo de la hipertensión inducida por el embarazo. Su uso en el tratamiento de la hipertensión esencial no se recomienda basado en la evidencia de una mayor eficacia y seguridad de otros medicamentos (20a LME OMS). Page 9 of 12

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Strategic Fund Medicine List / Lista de Medicamentos del Fondo Estratégico

Amidotrizoate HORMONES, ENDOCRINE MED. Contraceptives Oral hormonal contraceptives Ethinylestradiol + levonorgestrel Ethinylestradiol + norethisterone Levonorgestrel Injectable hormonal contraceptives Medroxyprogesterone acetate Medroxyprogesterone acetate + estradiol cypionate Norethisterone enantate Insulins and other antidiabetic agents Insulin soluble

Intermediate-acting insulin Glibenclamide Metformin MEDICINES AFFECTING THE BLOOD Antianaemia medicines Recombinant Human Erythropoietin Recombinant Human Erythropoietin Medicines affecting coagulation

140mg to 420mg iodine (sodium or Meglumine salt)/ml in 20ml ampoule

30µg + 150µg 35µg + 1.0mg 30µg; 750µg (pack of two); 1.5mg 150mg/ml in 1ml vial. 25mg + 5mg 200mg/ml in 1ml ampoule 40 IU/ml; 100 IU/ml in 10ml vial 40 IU/ml; 100 IU/ml in 10ml vial (coumpound insulin zinc suspension or isophane insulin) 2.5mg; 5mg 500mg (hydrochloride)

2,000-5,000 UI/ml 20,000-50,000 UI/ml

0.5mg; 1mg; 2mg; 5mg (sodium salt) ANTIALLERGICS AND MEDICINES USED IN ANAPHYLAXIS Warfarin

Dexamethasone Dexamethasone

4mg/ml in 1ml ampoule (disodium phosphate salt)

Injection

Radiocontrast Media

Tablet Tablet

Contraception

Tablet

Contraception

Depot Injection Injection Oily Injection

Contraception Contraception

Injection

Injection

Diabetes

Tablet Tablet

Injection Injection

Anemia

Tablet

Anticoagulant

Injection

2 mg Tablet 100mg (sodium succinate) in Powder for Hydrocortisone vial Injection MUSCLE RELAXANTS (PERIPHERALLY-ACTING) AND CHOLINESTERASE INHIBITORS Powder for Vecuronium 10mg (bromide) in vial Injection OXYTOCICS AND ANTIOXYTOCICS Oxytocics Oxytocin 10 UI in 1 ml ampoule Injection 200µg (hydrogen maleate) in Ergometrine Injection 1ml ampoule Mifepristone – Misoprostol 200mg - 200µg Tablets Misoprostol 200µg Tablet ANTICONVULSANT AND ANTIEPILEPTIC 25mg; 50mg; 100mg Phenytoin Capsule (sodium salt) 50mg/ml (sodium salt) in Phenytoin Injection 5ml vial

Antiemetic; Anti-allergic /Anaphylaxis; Cytotoxic; Palliative care Palliative care Anaphylaxis; Cytotoxic Muscle Relaxant

Oxytocic Oxytocic

Anticonvulsant; Antiepileptic

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Strategic Fund Medicine List / Lista de Medicamentos del Fondo Estratégico

Phenytoin

Phenobarbital Phenobarbital Carbamazepine

25mg/5 ml; 30mg/5 ml 50mg/ml in 5ml vial (sodium salt) 15mg/5 ml 15mg; 100mg 100mg/5 ml

Carbamazepine

100mg; 200mg

Carbamazepine

100mg; 200mg

Phenobarbital

Diazepam Magnesium sulfate

5mg/ml in 0.5ml; 2ml; 4ml tubes 500mg/ml in 2ml or 10ml ampoule 200mg; 500mg (sodium valproate)

Valproic acid

100mg 200mg/5ml 100mg/ml in 4ml ampoule; 100mg/ ml in 10ml ampoule

Oral Solution Injection Oral Solution Tablet Oral Solution Tablet (chewable)

Anticonvulsant; Antiepileptic

Tablet (scored) Gel or; Rectal solution Injection Tablet (entericcoated) Tablet (crushable) Oral solution

Anticonvulsant; Antiepileptic Medicine used in bipolar disorders Anticonvulsant; Antiepileptic

Injection

PSYCHOTHERAPEUTIC MEDICINES

Haloperidol

25mg (hydrochloride)/ml in 2ml ampoule. 25mg (hydrochloride)/5 ml 100mg (hydrochloride) 25mg (decanoate or enantate) in 1ml ampoule 5mg in 1ml ampoule

Haloperidol

2mg; 5mg

Tablet

10mg; 25mg (hydrochloride)

Tablet

Chlorpromazine Chlorpromazine Chlorpromazine Fluphenazine

Injection Oral Solution Tablet

Psychotic Disorders

Injection Injection

Medicines used in mood disorders Amitriptyline

Fluoxetine 20mg (hydrochloride) Fluoxetine 20mg (hydrochloride) Medicines used in bipolar disorders Lithium carbonate 300mg Lithium carbonate 300mg Medicines used for disorders due to psychoactive substance use Nicotine replacement therapy (gums) 2mg; 4mg (as polacrilex) Nicotine replacement therapy (patch)

5mg to 30mg/16 h; 7mg to 21mg/24h

Capsule Tablet

Palliative Care; Depressive Disorders Palliative Care; Depressive Disorders

Capsule Tablet

Bipolar Disorder

Gums Transdermal patch

Tobacco cessation

21

Treatment with 10mg should be utilized only in palliative care. - Tratamiento con 10mg solo debería ser utilizado en cuidados paliativos. Page 11 of 12

21

Strategic Fund Medicine List / Lista de Medicamentos del Fondo Estratégico

ANTIPARKINSONISM MEDICINES Biperiden Biperiden GASTROINTESTINAL MEDICINES Antiulcer Medicines Omeprazole

5mg (lactate) in 1ml ampoule 2mg (hydrochloride)

20 mg; 40 mg 10 mg; 20 mg; 40 mg

25 mg/ml (as hydrochloride) in 2-ml ampoule Ranitidine 150 mg (as hydrochloride) 75 mg/5 ml (as hydrochloride) MEDICINES ACTING ON THE RESPIRATORY TRACT Antiasthmatic and medicines for chronic obstructive pulmonary disease

Beclometasone

Ipratropium bromide

Salbutamol

50 micrograms (dipropionate) per dose; 100 micrograms (dipropionate) per dose (as CFC free forms) 20 micrograms/metered dose 100 micrograms (as sulfate) per dose 50 micrograms (as sulfate)/ml 100 micrograms (as sulfate) per dose 5 mg (as sulfate)/ml

Injection

Parkinson’s Disease

Tablet

Powder for oral liquid in Sachets Solid oral dosage form Injection

Antiulcer medicines

Tablet Oral Solution

Inhalation (aerosol) Inhalation (aerosol) Inhalation (aerosol) Injection in 5‐ml ampoule Metered dose inhaler (aerosol) Respirator solution for use in nebulizers

Antiasthmatic Medicines used for chronic obstructive pulmonary disease (COPD)

OTHERS Calcium gluconate

100mg/ml in 10ml ampoule

Injection

Specific Use Antidotes and Others Substances Used in Poisoning; Vitamins and Minerals

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